If you are making money through Google Adsense Program then you also need to make sure that you are optimizing the advertisements which appear on your blog because there is no point in showing the maximum ad units on your blog and making the lowest revenue out of it. Generally its preferred to use 2 Text Ad Units and 1 Link Ad unit on your blog. I will give you a complete list of recommendations for a normal web blog.

Generally the Google Adsense Team would recommend you to use a 300×250 Ad Slot because most of the advertisers submit ads in that standard size and this is the reason you should try to implement atleast one of these ad size. Generally its preferred to use this one on the blog’s top sidebar or else below the article, since this is a ad spot which would get direct visitors.

Implementing Google Custom Search box is also another effective way to make money because not only it searches for the best search results, you can even show advertisements within the search results either in the top, sidebar or the bottom based on your theme. You can implement upto 2 search boxes on your blog, on in the top right side or the center and one in the bottom of your blog posts which can be easily accessible by your readers. You should try out the changes by removing the default blog search with Adsense custom search along with different placements.

If your visitors count keeps changing in the weekend then you can try out different stuff like keeping less ads on low traffic days and if you see a spike in the traffic you can go for higher ad slots, also its recommended to go for randomizing ad colors for higher CTR. If you have a colored background of your blog theme, then try to keep the same background for the advertisements so they could look better and you can expect higher CTR.

Some people report that using a 728×90 ad slot works awesome for them when compared to 468×60 but the actual answer is that it depends on your blog design, navigation, width, readers and lot more stuff which is why experimenting the different ad sizes is really important rather than just opting which others recommend.

For Experimenting & Analyzing :
- Record current performance
- Make distinct changes
- Monitor for a set time frame
- Compare performance
*repeat*

Dont forget to implement heatmaps in order to find out the most clicked areas of your blog and implement the advertisements in those areas for higher number of clicks along with section targeting.